Cd19 And Cd20 Normal Range

The anti cd20 mab ofatumumab was approved by fda in october 2009 for chronic lymphocytic leukemia.

Cd19 and cd20 normal range.

Cd20 is not expressed on hematopoietic stem cells pro b cells or normal plasma cells 1 plasmablasts and stimulated plasma cells may express cd20 2 cd20 is generally coexpressed on b cells with cd19 another b cell differentiation marker. Anti cd20 therapies are used to treat patients with various types of b cell lymphoma leukemia and immune disorders. 7 18 because of its ubiquity on all b cells it can function as a b cell marker and a target for immunotherapies targeting neoplastic lymphocytes. Lymphocytes absolute cd19 cells cd19 b cells methodology.

Wbcs are stained with fluorescently labeled monoclonal antibodies to cd14 cd19 cd20 and cd45 and run on a flow cytometer and the cd19 and cd20 antigen expression are analyzed. It s a protein found on the surface of b cells a type of white blood cell. Cd20 is the target of the monoclonal antibodies rituximab ocrelizumab obinutuzumab ofatumumab ibritumomab tiuxetan tositumomab and ublituximab which are all active agents in the treatment of all b cell lymphomas leukemias and b cell mediated autoimmune diseases. Lymphocyte sub set normal ranges.

The cd19 antigen plays an important role in clinical oncology. Reference range s see laboratory report. Clotted samples cannot be tested. Cd19 expression is even maintained in b lineage cells that undergo neoplastic transformation.

Reference ranges for cd10 cd19 and cd20 were found to be 1 3 median 1 6 23 median 14 and 6 23 median 14 respectively table 2. Shearer wt et al. Cd20 is not expressed on hematopoietic stem cells pro b cells or normal plasma cells 1 plasmablasts and stimulated plasma cells may express cd20 2 cd20 is generally coexpressed on b cells with cd19 another b cell. Adult normal range chart.

Since cd19 is a hallmark of b cells the protein has been used to diagnose cancers that arise from this type of cell notably b cell lymphomas. Lymphocyte subsets in healthy children. Cd20 is a protein that is expressed on the surface of b cells starting at the pre b cell stage and also on mature b cells in the bone marrow and in the periphery. The distribution of these b cell subsets reference ranges based on gender is shown in table 3.

Pediatric normal range chart. The percentages of b cells were evaluated with the expression of cd10 cd19 and cd20. Cd19 is expressed on all normal mitogen stimulated and malignant b cells excluding plasma cells.